1. Microcapsule Enabled Multicatalyst System
Sarah L. Poe, Muris Kobasˇlija, and D. Tyler McQuade*
J. Am. Chem. Soc. 2006, 128,

2. One-Pot Multistep Reactions
advantage
Be effective at reducing the waste and cost of a synthetic route
decrease the number of work-ups and purifications
decrease the the volume of solvent
These reactions are especially useful when multiple catalysts are used so that one traps an unstable intermediate formed by the other.
imitation
a relatively small number of systems where the catalysts are compatible with each other.

3. Site–isolated catalysts
= polystyrene P
Patchornik, A. et al. J. Am. Chem. Soc. 1981, 103,

4. Helms, B. et al. Angew. Chem. Int. Ed. 2005, 44,6384 – 6387.

5. Gelman, F. et al. J. Am. Chem. Soc. 2000, 122, 11999-12000.

7. Synthesis of microencapsulated poly(ethyleneimine) catalyst
(0.15 g/mL PEI in 6.0 mL MeOH and 1.5 mL CHCl3
Span 85 / cyclohexane (2% v/v)
2 min
Span 85 (Sorbitan trioleate)
C60H108O8
PEI =
1.0 mL 2,4-tolylene diisocyanate (TDI)/ 9.0 mL cyclohexane
polymerization
1 min
cyclohexane
(stopped)
TDI =
washed with hexanes

8. Ni(II)–bis[(R,R)-N,N’-Dibenzylcyclohexane-1,2-diamine]Br2
82 %
Evans, D. A. et al. J. Am. Chem. Soc. 2005, 127,

9. dimethyl
malonate

10. APS : aminopropylsilica heterogeneous catalysts
TEOS (Tetraethyl Orthosilicate): (C2H5O)4Si
ATS (3-aminopropyl)triethoxysilane : NH2(CH2)3Si(OC2H5)3
Sartori, G. et al. J. Catal. 2004, 222,

12. Michael Addition reactions