1. Gene Evolution: Getting Something from Nothing
Caroline M. Weisman, Sean R. Eddy 
Current Biology 
Volume 27, Issue 13, Pages R661-R663 (July 2017)
DOI: /j.cub
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2. Figure 1 A Drake equation for the steps of protogene formation.
To become a protogene, a non-genic sequence must become transcribed, become translated, and have a beneficial function. Gray represents an initially random or non-genic sequence. Colored boxes indicate acquisition of the necessary sequence signals for transcription (red), translation (blue), and function (orange). We show the ‘function’ step as a folded protein, but an unstructured amino acid sequence may have a beneficial function, and conversely, well-folded proteins need not have a beneficial function.
Current Biology  , R661-R663DOI: ( /j.cub )
Copyright © 2017 Elsevier Ltd Terms and Conditions