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Adipose Tissue Macrophages: Amicus adipem?

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Presentation on theme: "Adipose Tissue Macrophages: Amicus adipem?"— Presentation transcript:

1 Adipose Tissue Macrophages: Amicus adipem?
Justin I. Odegaard, Kirthana Ganeshan, Ajay Chawla  Cell Metabolism  Volume 18, Issue 6, Pages (December 2013) DOI: /j.cmet Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Adipose Tissue Macrophages Buffer Local Lipid Levels through a Program of Lysosomal Lipid Metabolism Chronic overnutrition dramatically remodels adipose tissue architecture, driving adipocyte expansion and the infiltration of numerous immune cells, including macrophages. Triglycerides released from overburdened adipocytes are taken up by tissue-resident macrophages that function to buffer fatty acid release into circulation through a lysosome-dependent mechanism of lipid catabolism. ATM, adipose tissue macrophages. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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