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Antigen to the Node: B Cells Go Native

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Presentation on theme: "Antigen to the Node: B Cells Go Native"— Presentation transcript:

1 Antigen to the Node: B Cells Go Native
David Tarlinton, Andrew Lew  Immunity  Volume 26, Issue 4, Pages (April 2007) DOI: /j.immuni Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Representation of a Lymph Node Showing Pathways of Antigen Entry B cell (F, follicles) and T cell areas (PC, paracortex) are marked as are medullary sinus, high endothelial venules, afferent and efferent lymphatics, and the subcapsular sinus. Antigen enters the node either cell associated (pathway A) or free (pathway B). Pathway A results in the antigen moving within conduits (C) from the subcapsular sinus to the paracortex where it can be picked up by DC. Pathway B, described by Pape et al. (2007), concentrates free antigen in the follicles where it can activate B cells. Immunity  , DOI: ( /j.immuni ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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