1. Integrating Cells Into Tissues
Dawn M. Ford

2. A Brief Overview Cells aggregate into 5 main classes of tissue
Muscular
Nervous
Connective
Epithelial
Blood
Tissues are assembled to form organs

3. Cell Adhesion
Allows cells to aggregate & provides means for bidirectional transfer of information
Cell-to-cell adhesion
Cell adhesion molecules (CAMs)
Cell-matrix adhesion
Adhesion receptors bind to extracellular matrix (ECM)

4. Cell-To-Cell Adhesion

5. CAMs Homotypic or heterotypic adhesion
Homophilic or heterophilic binding
Broadly distributed or clustered in cell junctions
Long lasting adhesions or transient

6. Four Major CAM Families
Cadherins
Ca2+ dependent interactions
Selectins
Recognize glycoproteins & glycolipids
Immunoglobulin-Superfamily
Ca2+ independent interactions
Integrins
Multi-functional

7. Cell-Matrix Adhesion

8. Extracellular Matrix Proteoglycans Collagens
Soluble Multiadhesive Matrix Proteins

9. The Big Picture Adhesions very important in animal tissues
Formation
Composition
Architecture
Function
Adhesion molecules are highly conserved proteins
Complex organisms have depended on their evolution

10. The End La Fin Das Ende Het Eind l'estremità