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Targeting amino acid metabolism for cancer therapy Michael J. Lukey1, William P. Katt1 and Richard A. Cerione1,2,* 1Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA 2Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA *Corresponding author: Cerione, R.A.
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Table S1. Amino acid and selected metabolite concentrations in blood serum, selected tissues, HeLa cells, and culture media References Takach, E. et al. (2014) High-throughput quantitation of amino acids in rat and mouse biological matrices using stable isotope labeling and UPLC-MS/MS analysis. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 964, Psychogios, N. et al. (2011) The human serum metabolome. PLoS One 6, e16957 Halámková, L. et al. (2012) Enzymatic analysis of a-ketoglutarate – a biomarker for hyperammonemia. Talenta 100, 7-11 Filho, J.C. et al. (1997) Simultaneous measurements of free amino acid patterns of plasma, muscle and erythrocytes in healthy human subjects. Clin. Nutr. 16, Montanari, A. et al. (1988) Free amino acids in plasma and skeletal muscle of patients with liver cirrhosis. Hepatology 8, Roth, E. et al. (1985) Amino acid concentrations in plasma and skeletal muscle of patients with acute hemorrhagic necrotizing pancreatitis. Clin. Chem. 31, Barle, H. et al. (1996) The concentrations of free amino acids in human liver tissue obtained during laproscopic surgery. Clin. Physiol. 16, Kami, K. et al. (2013) Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry. Metabolomics 9, Hirayama, A. et al. (2009) Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 69, Chen, W. et al. (2016) Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism. Cell 166,
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