1. Volume 132, Issue 1, Pages 415-431 (January 2007)
Proliferating Cholangiocytes: A Neuroendocrine Compartment in the Diseased Liver 
Domenico Alvaro, Maria Grazia Mancino, Shannon Glaser, Eugenio Gaudio, Marco Marzioni, Heather Francis, Gianfranco Alpini 
Gastroenterology 
Volume 132, Issue 1, Pages (January 2007)
DOI: /j.gastro
Copyright © 2007 AGA Institute Terms and Conditions

2. Figure 1
As shown in this rat liver cholangiogram, the intrahepatic biliary epithelium is a complex 3-dimensional network of interconnected ducts lined by cholangiocytes. The rat cholangiogram shows a portion of the intrahepatic biliary tree at the periphery of the liver. The contrast agent, renographin, was injected in a retrograde fashion into bile ducts of a normal rat liver. The image of bile ducts was obtained employing a microfocus magnification mammography instrument. Original magnification, 320×. Reproduced with permission from ref. 2.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

3. Figure 2
Liver from rats with BDL for 3 weeks. The luminal surface of bile ducts is shown, with lining cholangiocytes that are rich of microvilli and sparse, long cilia (enlarged box). (Scanning electron microscopy, original magnification, 3,500×).
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

4. Figure 3
This depicts the different peptides (regulating the balance between cholangiocyte proliferation/apoptosis) secreted by proliferating cholangiocytes and their interactions with other cells.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions

5. Figure 4
Schematic drawing of the growth factors, gastrointestinal hormones, and neuropeptides that affect cholangiocyte proliferation with decreases or increases with biliary ductal mass.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2007 AGA Institute Terms and Conditions