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Filling the (SR)GAP in Excitatory/Inhibitory Balance

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Presentation on theme: "Filling the (SR)GAP in Excitatory/Inhibitory Balance"— Presentation transcript:

1 Filling the (SR)GAP in Excitatory/Inhibitory Balance
Jaichandar Subramanian, Elly Nedivi  Neuron  Volume 91, Issue 2, Pages (July 2016) DOI: /j.neuron Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 SRGAP2A-Mediated Regulation of Excitatory and Inhibitory Synapse Density and Maturation In normal mice, excitatory and inhibitory synapses increase in size during development and reach adult levels by the late postnatal period (left panel). The FBAR and SH3 domains of SRGAP2A promote maturation of dendritic spines and inhibitory synapses, respectively. The Rho-GAP domain suppresses clustering of Gephyrin and initiation of new spines. When SRGAP2A is knocked down or is antagonized by SRGAP2C expression (right panel), Rho-GAP-mediated suppression is relieved and the density of spines and Gephyrin clusters increases. Loss of FBAR and SH3 domain function delays all synaptic maturation. Synapse maturation is protracted as compared to wild-type, but synapses reach wild-type size by adulthood. Consequently, adult synaptic densities are elevated, but excitatory/inhibitory ratios are maintained. Neuron  , DOI: ( /j.neuron ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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