1. Drug reactions
Professor W K Jacyk

2. Drug reactions Cutaneous drug reactions are very common
Only few drugs cause characteristic eruptions
The same drug may cause different skin lesions in different patients and in the same patient at different time

3. Frequency of cutaneous drug reactions reflects an ‘innate’ capacity of the particular drug to cause this adverse effect and the frequency of its usage
Once- penicillins
Now- anticonvulsives
-NSAIDS
-ACE inhibitors

4. Fixed drug eruption

14. Management Value of a detailed history Very limited value of tests
Rechallenge- caution!
Symptomatic treatment depending on the morphology and severity of the reaction
Genetic background of propensity to some drug reactions
Allopurinol, procainamide, azathioprine