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S. Silva, S. J. Hooper, M. Henriques, R. Oliveira, J. Azeredo, D. W

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Presentation on theme: "S. Silva, S. J. Hooper, M. Henriques, R. Oliveira, J. Azeredo, D. W"— Presentation transcript:

1 The role of secreted aspartyl proteinases in Candida tropicalis invasion and damage of oral mucosa 
S. Silva, S.J. Hooper, M. Henriques, R. Oliveira, J. Azeredo, D.W. Williams  Clinical Microbiology and Infection  Volume 17, Issue 2, Pages (February 2011) DOI: /j x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Colonization profile of Candida tropicalis strains infecting human oral epithelium after 12 h of incubation. *Presence of filamentous forms. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Confocal laser scanning microscopy images of Candida tropicalis strains infecting human oral epithelium after 12 h of incubation. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

4 FIG. 3 Confocal laser scanning microscopy images of Candida tropicalis strains infecting human oral epithelium after 24 h of incubation. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

5 FIG. 4 Relative lactate dehydrogenase activity measured in the human oral epithelium tissue culture supernatant after 12 h (▪) and 24 h (█) incubation with different Candida tropicalis strains; and in the presence of pepstatin A at 24 h (□). *Strain statistically different from the other strains (p <0.05). Error bars represent the SD. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

6 FIG. 5 Confocal laser scanning microscopy images of Candida tropicalis strains infecting human oral epithelium after 24 h in presence of 15 μL/mL pepstatin A. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions


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