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Tailor-Made Renal Cell Carcinoma Vaccines

Published byΕιρηναίος Στεφανόπουλος Modified over 6 years ago

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Presentation on theme: "Tailor-Made Renal Cell Carcinoma Vaccines"— Presentation transcript:

1 Tailor-Made Renal Cell Carcinoma Vaccines
Glenn Dranoff  Cancer Cell  Volume 22, Issue 3, Pages (September 2012) DOI: /j.ccr Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Schema for Developing Tailor-Made Renal Cell Carcinoma Vaccines Naturally processed peptides derived from highly expressed oncogenic proteins are inoculated in conjunction with GM-CSF to stimulate tumor-specific CD8+ cytotoxic T cells. The administration of cyclophosphamide prior to vaccination attenuates FoxP3+ Tregs, resulting in more effective and durable anti-tumor immunity. High levels of apolipoprotein-A1 (APO-A1) and CCL17 are associated with superior vaccine outcome. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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