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Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control

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Presentation on theme: "Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control"— Presentation transcript:

1 Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control
Peter K. Jackson  Molecular Cell  Volume 51, Issue 4, Pages (August 2013) DOI: /j.molcel Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control The Nek8/NPHP9 is important in the function of primary cilia and in blocking pediatric renal degeneration in the disease nephronophthisis (NPHP). These ciliary functions of Nek8 are highlighted in red. Nek8 kinase also controls the DNA damage checkpoint through the direct control of cyclin A kinase activity and indirectly via the ATR-Chk1 pathway, thus limiting DNA damage in response to replication stress. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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