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Volume 49, Issue 1, Pages 1-2 (January 2006)

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1 Volume 49, Issue 1, Pages 1-2 (January 2006)
Vesicular Monogamy?  David E. Krantz  Neuron  Volume 49, Issue 1, Pages 1-2 (January 2006) DOI: /j.neuron Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 How Many Transporters Does a Vesicle Need?
The number of vesicular transporters required to fill a synaptic vesicle with neurotransmitter is not known. Mutations in the dvglut gene decrease transporter expression such that most vesicles are empty and do not produce minis. It is therefore likely that vesicles with only one transporter (blue pyramid) produce the few minis that remain in the mutant NMJ. dvglut mutant minis are equal in size to wild-type (see box), suggesting a model in which one transporter normally fills a synaptic vesicle to capacity. Neuron  , 1-2DOI: ( /j.neuron ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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