1. Wisconsin Genomics Initiative
Medical
Discovery
Triangle
Wisconsin Medical Research Triangle 1

2. Marshfield Madison Milwaukee MCRF MCW UW Milwaukee UWSMPH
Genetic & Genomic Analysis
Diverse Urban & Pediatric Patient Populations
High Through-Put Genotyping
UW Milwaukee
Urban & Environmental Health
Community Engagement
School of Nursing
Marshfield
Madison
Milwaukee
UWSMPH
Regenerative Medicine
Statistical & Computational Analysis
Super-Computing Capability
MCRF
Rural Cohort Comprised of 20,000 Adults
Biomedical Informatics
Phenotyping

3. WGI Vision
Vision:
To be able to predict for individual patients in a clinical setting the risks of disease susceptibility and treatment response using the combined power of cutting edge genetic, phenotypic, and environmental analyses.
Thereby, making the promise of personalized medicine a reality for the citizens of Wisconsin and beyond.

4. WGI Goals
Phase I
Create the medical research infrastructure to build and test a unique scientific platform that is capable of predicting disease susceptibility and treatment response to a high degree of accuracy; and to make it widely available to scientists across the country.
Phase II
Use this unique scientific platform for discovery in multiple disease areas and treatment methods; and to improve its capability by expanding research cohorts, increasing the number of genetic markers, increasing the amount of environmental and clinical data, and improving the computational algorithms. 4 4

5. WGI Cores and Major Functions5 5

6. Predictive Personalized Medicine
Individual Patient
G + C + E
Repeat for thousands of patients
Predictive Personalized Medicine
Genetic,
Clinical,
&
Environmental
Data
Predictive Model for
Disease Susceptibility
& Treatment
Response
State-of-the-Art
Machine
Learning
Data picture is from:
Machine picture is from Microsoft Clip Art j jpg j jpg :
Pill picture is from Microsoft Clip Art j jpg :
Black stick figure picture is from:
Personalized medicine picture is from:
Personalized
Treatment
Repeat for hundreds of diseases and treatments 6

7. Building Accurate Predictive Models( +
& ) = P E C G
Complex combinations of variables are required for accurate prediction
The more we know about individual patients, greater the probability of prediction

8. What Makes WGI Unique Among Large Genetic Research Projects?
Is a natural laboratory
PMRP is a population-based study with a stable population
PMRP cohort is consented for ongoing clinical data collection over a lifetime through Electronic Health Record
High level of compliance for recommended health screenings to classify controls
Genome Wide Association Studies using Machine Learning
Through the Governor’s eHealth Care Quality and Patient Safety Initiative, Wisconsin will be among the first states to have statewide adoption of electronic health record standards and capability for statewide health information exchanges
As a natural laboratory and with eHealth exchange capability, WGI can expand dramatically and efficiently beyond the planned 50,000-person combined rural, urban, and children’s cohorts

9. Why Wisconsin?
Approximately 2% of US population providing size, manageability, and representativeness
With additional subject recruitment in Milwaukee, WGI will have breadth of research cohorts
Rural and Urban
Northern European and Minorities
Adults and Children
Economically advantaged and disadvantaged
A value-added project, does not start from scratch
The major elements of the strategy are in place, including the DNA samples, genotyping capability, phenotyping protocols, machine learning algorithms, and super-computing capabilities
Can begin immediately upon funding and will have meaningful results within 2 years
WGI and the Wisconsin Action Plan for Health Care Quality and Safety are mutually supportive
Intellectual capital strong and able to grow with an influx of resources

10. Benefits to the State
Leadership in an international movement to transform health care delivery using the human genome
Save lives and improve medical care
Reduce health care costs
Develop heath care education programs here first, drawing talent from all over the globe
Strengthen the economy
Increased research dollars
Creation of “spin-off” companies and new high tech jobs
Attractive location for pharmaceutical companies
Additional benefits for urban populations and underserved communities
Addresses unique health care issues of urban populations
Increases access to health care for all by making it more affordable
Studies those chronic diseases that are increasingly devastating families in underserved communities

11. Summary
Wisconsin has in its Medical Research Triangle all of the resources necessary to make a major advancement in the application of genetic science to human health
The Wisconsin Genomics Initiative is positioned to make the promise of personalized medicine and personalized health care a reality
The Wisconsin Genomics Initiative aligns with the priorities of the National Institutes of Health, the US Department of Health and Human Services, and the State of Wisconsin
The Wisconsin Genomics Initiative offers a rare opportunity to bring the UW School of Medicine and Public Health, the Medical College of Wisconsin, UW-Milwaukee, and Marshfield Clinic together to meet important scientific and public health needs 11