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Kv1.1 Takes a deTOR from the Axon to the Dendrite

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Presentation on theme: "Kv1.1 Takes a deTOR from the Axon to the Dendrite"— Presentation transcript:

1 Kv1.1 Takes a deTOR from the Axon to the Dendrite
Eliana Clark, Helene Vacher, James S. Trimmer  Neuron  Volume 52, Issue 3, Pages (November 2006) DOI: /j.neuron Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Regulation of Dendritic Kv1.1 Translation by Synaptic Activity Cartoon showing that Kv1.1 mRNAs are transported from the neuronal soma into the dendrite within granules and/or through association with RNA binding protein complexes. Translation occurs upon association of mRNAs with ribosomes at or near synaptic sites, and their subsequent association with ER membranes. On the right-hand side is the local situation near an active synapse, where NMDA receptor-mediated suppression of Kv1.1 translation occurs through the PI3 kinase-mTOR pathway. In contrast, near inactive synapses (left-hand side) when the mTOR pathway is not active the local synthesis of Kv1.1 protein is permitted. Neuron  , DOI: ( /j.neuron ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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