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Fatty acid oxidation in normotriglyceridemic men
Brian Benjamin, MD, Yasuyo Wada, RD, PhD, Scott M. Grundy, MD, PhD, Magdalene Szuszkiewicz-Garcia, MD, Gloria Lena Vega, PhD Journal of Clinical Lipidology Volume 10, Issue 2, Pages (March 2016) DOI: /j.jacl Copyright © 2016 National Lipid Association Terms and Conditions
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Figure 1 Plot of plasma triglyceride levels during an extended fat tolerance test for the group as a whole. This curve shows the rise in plasma triglyceride levels and the eventual attainment of a steady state. Journal of Clinical Lipidology , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions
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Figure 2 Baseline (postabsorptive) levels of 3-β-hydroxybutyrate as a function of plasma levels of nonesterified fatty acids (A) or plasma triglycerides (B). Log of 3-β-hydroxybutyrate correlated positively with levels of nonesterified fatty acids (A). This association is consistent with the metabolic relation of precursor product. In contrast, levels of 3-β-hydroxybutyrate are inversely correlated with plasma triglyceride (B). Normal levels of plasma triglyceride are likely influenced by the extent of hepatic fatty acid oxidation. Journal of Clinical Lipidology , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions
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Figure 3 Levels of postprandial 3-β-hydroxybutyrate correlated positively with the levels of postprandial nonesterified fatty acids (A). In turn, postprandial levels of 3-β-hydroxybutyrate increased with a prolonged residence time of chylomicron triglyceride in plasma (B). Journal of Clinical Lipidology , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions
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Figure 4 Plots of levels of baseline 3-β-hydroxybutyrate and plasma triglyceride from a previously study cohort of men with a broad spectrum of plasma triglycerides.3 The curvilinear association of 3-β-hydroxybutyrate with plasma triglyceride is consistent with the results reported in this study. Normotriglyceridemic subjects have a higher level of 3-β-hydroxybutyrate and as the triglyceride levels rise, levels of 3-β-hydroxybutyrate are not linearly associated with the triglyceride levels. These data support the contention that low levels of plasma triglyceride result from an efficient oxidation of nonesterified fatty acids. Journal of Clinical Lipidology , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions
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