1. Sulfonamides and Trimethoprim
Chapter 84
Sulfonamides and Trimethoprim

2. Sulfonamides and Trimethoprim
Broad spectrum antibiotics
Suppresses bacterial growth by inhibiting folic acid
Urinary tract infections
Adverse effects
Hypersensitivity reactions—Stevens-Johnson syndrome
Hematologic effects
Kernicterus
Crystalluria

3. Trimethoprim (Proloprim and Trimpex)
Urinary tract infections
Hematologic effects

4. Trimethoprim-Sulfamethoxazole
Uses
Uncomplicated urinary tract infection
Pneumocystis carinii
– GI infections
Adverse effects
Gastrointestinal
Rash
– Crystalluria