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Hepatitis Due to Human Herpesvirus 6 after Hematopoietic Stem Cell Transplantation  Joshua A. Hill, MD, Danielle Zerr, MD, MPH, Ruth Hall Sedlak, PhD,

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Presentation on theme: "Hepatitis Due to Human Herpesvirus 6 after Hematopoietic Stem Cell Transplantation  Joshua A. Hill, MD, Danielle Zerr, MD, MPH, Ruth Hall Sedlak, PhD,"— Presentation transcript:

1 Hepatitis Due to Human Herpesvirus 6 after Hematopoietic Stem Cell Transplantation 
Joshua A. Hill, MD, Danielle Zerr, MD, MPH, Ruth Hall Sedlak, PhD, Keith R. Jerome, MD, PhD, David Myerson, MD, PhD  Biology of Blood and Marrow Transplantation  Volume 20, Issue 2, Pages S228-S229 (February 2014) DOI: /j.bbmt Copyright © Terms and Conditions

2 Fig.1 Quantitative plasma human herpesvirus 6 (HHV-6) viral loads (VL) and liver enzyme trends during hospitalization. ALT, alanine aminotransferase; AP, alkaline phosphatase. Biology of Blood and Marrow Transplantation  , S228-S229DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Fig. 2 Immunohistochemical staining (brown) of a number of HHV-6 proteins. A) Early antigen (E A) p41 staining in the cytoplasm of hepatocytes and Kupffer cells (20X). Inset shows positively staining bodies in the cytoplasm of hepatocytes (60X) [bar = 100 μM]. B) EA p41 staining of control liver specimen with hemosiderosis showing light background staining in hepatocytes but not in Kupffer cells. C) Viral capsid antigen (VCA) p140 staining in Kupffer cell cytoplasm, and in a punctate distribution in hepatocyte cytoplasm, both with a patchy distribution. D) VCA stained control with hemosiderosis showing minimal background staining. E) Envelope glycoprotein (EG) gH stains similarly to VCA with an identical patchy distribution. F) CD68 staining of the subject liver demonstrating Kupffer cells. Biology of Blood and Marrow Transplantation  , S228-S229DOI: ( /j.bbmt ) Copyright © Terms and Conditions


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