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The Ripoptosome: Death Decision in the Cytosol

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1 The Ripoptosome: Death Decision in the Cytosol
Mathieu J.M. Bertrand, Peter Vandenabeele  Molecular Cell  Volume 43, Issue 3, Pages (August 2011) DOI: /j.molcel Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Cellular Stress and Ripoptosome Formation
Different forms of cellular stress converge on the formation of the Ripoptosome (a FADD/RIP1/caspase-8 complex), which is sensitized by IAP depletion and FLIP isoform modulation. The Ripoptosome, in the absence or presence of RIP3, can either lead to RIP1 kinase-dependent apoptosis or RIP1 kinase-dependent necrosis, respectively. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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