1. Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives
by Willem M. Lijfering, Jan-Leendert P. Brouwer, Nic J. G. M. Veeger, Ivan Bank, Michiel Coppens, Saskia Middeldorp, Karly Hamulyák, Martin H. Prins, Harry R. Büller, and Jan van der Meer
Blood
Volume 113(21):
May 21, 2009
©2009 by American Society of Hematology

2. Flow diagram of the family cohort
Flow diagram of the family cohort. * indicates probands were classified according to their index defect.
Flow diagram of the family cohort. * indicates probands were classified according to their index defect. In case of multiple defects, the index defect was chosen in the following order: antithrombin deficiency, protein C deficiency, protein S deficiency, FV Leiden, prothrombin 20210G>A, high factor VIII levels, and hyperhomocysteinemia.
Willem M. Lijfering et al. Blood 2009;113:
©2009 by American Society of Hematology

3. Event-free survival of first venous thrombosis in relatives with thrombophilic defects. * indicates that when analyzing idiopathic events, provoked events were censored and vice versa.
Event-free survival of first venous thrombosis in relatives with thrombophilic defects. * indicates that when analyzing idiopathic events, provoked events were censored and vice versa.
Willem M. Lijfering et al. Blood 2009;113:
©2009 by American Society of Hematology

4. Risk of first venous thrombosis associated with cosegregation.
Willem M. Lijfering et al. Blood 2009;113:
©2009 by American Society of Hematology

5. Event-free survival of recurrent venous thrombosis in relatives of probands with thrombophilic defects.
Event-free survival of recurrent venous thrombosis in relatives of probands with thrombophilic defects.
Willem M. Lijfering et al. Blood 2009;113:
©2009 by American Society of Hematology