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Looking within for Vision

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Presentation on theme: "Looking within for Vision"— Presentation transcript:

1 Looking within for Vision
John G. Flannery, Kenneth P. Greenberg  Neuron  Volume 50, Issue 1, Pages 1-3 (April 2006) DOI: /j.neuron Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Photoisomerization of Retinal Gates Ionic Currents through Channelrhodopsin-2 Channelrhodopsin-2 (Chop2) is a seven transmembrane domain cation selective channel that becomes photoswitchable when bound to the chromophore 11-cis or all-trans retinal. The chromophore bound channel (designated ChR2) opens in response to 460 nm light, allowing cation flow in and depolarizing the cell. In response to darkness, the channel closes allowing the cell to once again reach its resting membrane potential. Bi et al. express a truncated Chop2 fragment (Met1-Lys315) fused to green fluorescent protein (GFP) exogenously in retinal ganglion cells of blind mice. Neuron  , 1-3DOI: ( /j.neuron ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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