1. Volume 147, Issue 3, Pages 562-565 (September 2014)
Hippo/YAP, β-Catenin, and the Cancer Cell: A “Ménage à Trois” in Hepatoblastoma 
Karl G. Sylvester 
Gastroenterology 
Volume 147, Issue 3, Pages (September 2014)
DOI: /j.gastro
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2. Figure 1
Proposed model for the interaction between YAP and β-catenin signaling in fetal-type hepatoblastoma (HB). β-Catenin and Yap are nuclear specifically in HB and not in hepatocarcinoma, and in mice each pathway independently does not lead to HB, whereas their coactivation results in efficient tumorigenesis. This occurs through (1) direct interactions between YAP and truncated β-catenin (delta-exon2); (2) transcriptional activation of YAP target genes by β-catenin/Tcf and of β-catenin targets by YAP/TEAD; (3) a control of β-catenin over Yap transcription; (4) the involvement of TRIB2 that has been shown in another publication (Wang et al17) to be a target of β-catenin targeting Yap to β-TrCP directed degradation (annotated with *). Dvl, Dishevelled; Fz, Frizzled; NF2, Neurofibromatosis 2.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2014 AGA Institute Terms and Conditions