1. Volume 139, Issue 5, Pages 1549-1558.e1 (November 2010)
Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis 
Archana S. Rao, Banny S. Wong, Michael Camilleri, Suwebatu T. Odunsi–Shiyanbade, Sanna McKinzie, Michael Ryks, Duane Burton, Paula Carlson, Jesse Lamsam, Ravinder Singh, Alan R. Zinsmeister 
Gastroenterology 
Volume 139, Issue 5, Pages e1 (November 2010)
DOI: /j.gastro
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2. Figure 1
Illustration of bile acid enterohepatic circulation and homeostasis and relevant proteins with genetic variation tested in this study.
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

3. Figure 2 Study flow chart and patient demographics.
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

4. Figure 3
Effects of placebo or CDC on overall colonic transit and time for AC emptying. *Overall significant difference among placebo and CDC groups (ANCOVA P = .005 for GC 24 and P = .028 for AC t½).
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

5. Figure 4
Correlation between gastric emptying and colonic transit for each treatment group.
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

6. Figure 5
Effects of treatment on AC colon emptying in relation to genotype. The upper panel shows results by genotype in the entire cohort (health and IBS-C). The lower panel shows results for KLB for the different phenotype subgroups and illustrates the genotype-by-treatment-by-phenotype interaction.
Gastroenterology  , e1DOI: ( /j.gastro )
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7. Supplementary Figure 1
Effect of CDC versus placebo on bowel function (stool consistency measured by Bristol Stool Form Scale; stool frequency measured as daily number of bowel movements; ease of passage of stool range: 1 = manual disimpaction to 7 = incontinence).
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions

8. Supplementary Figure 2
Relationship between baseline serum 7αC4 level and colonic transit in the placebo group.
Gastroenterology  , e1DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions