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Amy F.T. Arnsten, Daeyeol Lee, Christopher Pittenger  Cell 

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1 Risky Business: The Circuits that Impact Stress-Induced Decision-Making 
Amy F.T. Arnsten, Daeyeol Lee, Christopher Pittenger  Cell  Volume 171, Issue 5, Pages (November 2017) DOI: /j.cell Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Stress-Induced Changes in Decision-Making
(A) Just like humans, rats exposed to chronic stress make more “high-reward but high-cost” choices. (B) Friedman et al. (2017) reveal changes in striatal circuits that contribute to altered decision-making. While it has been well established that stress weakens the “top-down” influence of the prefrontal cortex, this study revealed the consequences on striatal physiology, where reduction in feed-forward inhibition by fast-spiking interneurons led to stronger striatal output from the projection neurons in striosomes, driving more high-risk/high-reward choices. Cell  , DOI: ( /j.cell ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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