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Macrophages Have a Grip on the Gut

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1 Macrophages Have a Grip on the Gut
Massimo Locati  Immunity  Volume 41, Issue 1, Pages (July 2014) DOI: /j.immuni Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Crosstalk of Muscularis Mucosae Macrophages and Enteric Neurons In the gut, muscularis propria macrophages are organized in layers between the longitudinal and circular muscles and the outer and the inner circular muscles. In these areas, macrophages establish a bidirectional interaction with enteric neurons, being sustained in their development by neuronal-derived CSF1 and by converse stimulating neuronal activity via BMP2 secretion. Enteric neurons then control gastrointestinal motility acting on smooth-muscle cells. Changes in the microbiome composition influence muscularis propria macrophages, which accordingly tune intestinal peristalsis acting on this network. Adapted from Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H. (2010). Ganong’s Review of Medical Physiology, 23rd Edition (New York: McGraw Hill Companies). Immunity  , 11-13DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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