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P. Castillo, C. Menéndez, A. Mayor, C. Carrilho, M. R. Ismail, C

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Presentation on theme: "P. Castillo, C. Menéndez, A. Mayor, C. Carrilho, M. R. Ismail, C"— Presentation transcript:

1 Massive Plasmodium falciparum visceral sequestration: a cause of maternal death in Africa 
P. Castillo, C. Menéndez, A. Mayor, C. Carrilho, M.R. Ismail, C. Lorenzoni, F. Machungo, N. Osman, L. Quintó, C. Romagosa, C. Dobaño, P.L. Alonso, J. Ordi  Clinical Microbiology and Infection  Volume 19, Issue 11, Pages (November 2013) DOI: / Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Massive sequestration of Plasmodium falciparum-infected erythrocytes (PfIE) in the capillaries of the central nervous system; (a) cortical vessel showing many parasitized erythrocytes (haematoxylin & eosin, 4009); (a′) high power field (10009) of a single vessel; (b) lung (2009) and (b′) heart (4009); showing massive accumulation of PfIE in the capillaries. Placenta of the same patient showing massive accumulation of infected maternal erythrocytes in the intervillous space (c) haematoxylin & eosin, 4009; (c′) haematoxylin & eosin, 1009, polarized light. Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Box plots showing the percentage of capillaries with parasites (a), mean number of parasites per capillary cross-section (b), and percentage of capillaries with macrophages containing haemozoin (c), in the central nervous system, kidney, lung and heart. All figures are based on counts of at least 100 capillaries. Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

4 FIG. 3 (a) Ring haemorrhages in the cortical white matter (haematoxylin & eosin, 100×); (a′) higher magnification showing a ring haemorrhage surrounding a parasitized vessel (haematoxylin & eosin, 200×); (b) intravascular thrombus in a vessel of the white matter. Some parasitized red blood cells are identified (haematoxylin & eosin 1000×); (b′) intravascular haemozoin-laden macrophage in a vessel of the white matter (haematoxylin & eosin 1000×); (c) lung showing oedema (haematoxylin & eosin, 200×); (c′) intra-alveolar haemorrhage in the lung (haematoxylin & eosin, 100×). Clinical Microbiology and Infection  , DOI: ( / ) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions


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