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Cross-Species Oncogenomics in Cancer Gene Identification

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Presentation on theme: "Cross-Species Oncogenomics in Cancer Gene Identification"— Presentation transcript:

1 Cross-Species Oncogenomics in Cancer Gene Identification
Daniel Peeper, Anton Berns  Cell  Volume 125, Issue 7, Pages (June 2006) DOI: /j.cell Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Cross-Species Oncogenomics Strategy
To identify candidate oncogenes, array CGH and expression analysis are used to compare genomic abnormalities (e.g., amplicons) between mouse and human tumors. Recurrent events serve as a filter to limit the number of candidate oncogenes. Selected genes (either alone or in combination) are then functionally assessed for tumorigenic or metastatic activity in the same murine genetic setting in which their mutation had occurred originally. Figure adapted from images kindly provided by L. Chin and S. Lowe. Cell  , DOI: ( /j.cell ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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