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Mother Centrioles Do a Cartwheel to Produce Just One Daughter

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Presentation on theme: "Mother Centrioles Do a Cartwheel to Produce Just One Daughter"— Presentation transcript:

1 Mother Centrioles Do a Cartwheel to Produce Just One Daughter
Jieyan V. Chen, Timothy L. Megraw  Developmental Cell  Volume 30, Issue 2, Pages (July 2014) DOI: /j.devcel Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 New Model for Centriole Duplication
In this model, the cartwheel (purple) is preassembled in the lumen of the mother centriole (gold) in a CPAP/SAS-4-dependent manner during S phase. This scaffold is then transferred to the outside surface of the mother through PLK4 and STIL/SAS-5 to initiate daughter centriole assembly. The nascent, engaged daughter centriole blocks additional cartwheel preassembly in the mother, preventing further duplication. Illustration by Jodi Slade. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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