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Figure 2 Prevention of antigen–antibody

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1 Figure 2 Prevention of antigen–antibody
immunocomplex deposition on the glomerular basement membrane Figure 2 | Prevention of antigen–antibody immunocomplex deposition on the glomerular basement membrane. a | A glomerular capillary and its basement membrane surrounded by podocytes. Anti-M-type phospholipase A2 receptor (PLA2R) antibodies are shown in the capillary lumen. b | Binding of circulating anti PLA2R autoantibodies to their specific cystein-rich domain (CysR), C-type lectin domain (CTLD)1 or CTLD7 epitopes expressed by the PLA2R receptor on the podocyte cell surface leads to the deposition of antigen–antibody subepithelial immunocomplexes that activate the complement system with secondary podocyte damage and proteinuria. In theory, antibody–antigen binding and the deposition of subepithelial immunocomplexes could be prevented by epitope-specific ligands that bind circulating antiPLA2R antibodies and prevent their binding to epitopes of the PLA2R antigen. Ruggenenti, P. et al. (2017) Treatment of membranous nephropathy: time for a paradigm shift Nat. Rev. Nephrol. doi: /nrneph

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