1. The clonal selection model of immunogenesis

2. Cell division and gene rearrangement
Figure 43.UN02
Stem cell
Cell division and gene rearrangement
Elimination of self-reactive B cells
Antigen
Clonal selection
Formation of activated cell populations
Antibody
Plasma cells
Memory B cells
Pathogen
Receptors bind to antigens

3. (b) Antigen receptor specificity
Figure 43.10b
Antibody C
Antibody A
Antibody B
Antigen
(b) Antigen receptor specificity

4. The common pathway of specific immunity

5. T cell antigen receptor Variable regions V V
Figure 43.11
Antigen- binding site
T cell antigen receptor
Variable regions V V C C
Constant regions
Disulfide bridge
Transmembrane region
 chain
 chain
Plasma membrane
T cell
Cytoplasm of T cell

6. Docking, then
activation by
interleukins
Cellular immunity

7. Lysis of infected cell by activated T – cytotoxic lymphocyte

8. The primary and secondary responses
IgM
IgG

9. Overview of specific immunity