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Viral genomes and Eukaryotic Virus Growth
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Figure 6.20 5
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Picornavirus (RNA) Life Cycle
Figure 6.23 8
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The poliovirus binds to poliovirus receptor (PVR) through its VP2 and VP3 subunits.
- A conformational change in VP1 allows insertion of the genome into the cytoplasm. Figure 11.12 9
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Poliovirus Replication
In the cytoplasm, the RNA is translated to make three large precursor peptides: P1–3. - All three peptides are eventually cleaved by proteases to generate 11 proteins. Figure 11.13A 10
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Influenza Virus Structure
The flu virus has no geometric capsid. RNA genome is loosely contained by a shell of matrix proteins. Figure 11.16 RNA segments are coated with nucleocapsid proteins (NPs). Two major envelope proteins: - Neuraminidase (NA) - Hemagglutinin (HA) 11
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The Genome of Influenza A Virus
Figure 11.17 14
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- Instant new strain can evade the immune system.
The key advantage of a segmented genome is that it facilitates recombination between two strains coinfecting the same cell. - Instant new strain can evade the immune system. Figure 11.18B 15
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Figure 11.21 16
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Reo virus ds RNA
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Herpes Simplex Virus Structure
An icosahedral capsid houses the dsDNA genome. Capsid is surrounded by a protein tegument, which is contained within an envelope with spike proteins. Figure 11.31A 18
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Figure 11.32 19
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Fig tRNA-like structure Stop codon Cap MTH RNP MP CP
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Figure 6-6 Viroids: infective RNA.
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Figure 6-7 Prion disease. sfmb2e_0607.jpg
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