1. SB 203580 Size: 10 mg M.W.=377.44 Batch No.: 1A/2004002 Description:
Cat # PKI-SB
15875 Gaither Drive
Gaithersburg, MD 20877
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This product is for laboratory research ONLY and not for diagnostic use
Description:
SB is a highly selective and cell permeable inhibitor of p38 mitogen-activated protein kinase with IC50 values of 50 and 500 nM for p38/SAPK2a and p38/SAPK2b respectively. Also inhibits the phosphoinositide-dependent protein kinase 1 (PDK1) at 10-fold higher concentrations (IC50 ~3-5 µM).  Displays fold selectivity over Lck, GSK3b and Akt/PKB. Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2 and thromboxane synthase.
PHYSICAL AND CHEMICAL PROPERTIES
Batch Molecular Formula: C21H16FN3OS
Batch Molecular Weight:
CAS No: [ ]
Physical Appearance: White solid
Melting Point (°C):
Solubility: DMSO to 25 mM 1eq. HCl to 100 mM
ANALYTICAL DATA
TLC: R f = 0.23 (Dichloromethane:Methanol [10:1]) HPLC: Shows 100% purity 1 H NMR: Consistent with authentic reference material
Molecular Structure
References: 1. Cuenda et al (1995) SB is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett Saklatvala et al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J. Biol. Chem Borsch-Haubold et al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB and PD J. Biol. Chem Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J
Storage: Desiccate at +4°C . Product shipped at ambient temperature.
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