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Volume 154, Issue 8, Pages e5 (June 2018)

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1 Volume 154, Issue 8, Pages 2068-2086.e5 (June 2018)
The Effect of Endoscopic Surveillance in Patients With Barrett’s Esophagus: A Systematic Review and Meta-analysis  Don Chamil Codipilly, Apoorva Krishna Chandar, Siddharth Singh, Sachin Wani, Nicholas J. Shaheen, John M. Inadomi, Amitabh Chak, Prasad G. Iyer  Gastroenterology  Volume 154, Issue 8, Pages e5 (June 2018) DOI: /j.gastro Copyright © 2018 AGA Institute Terms and Conditions

2 Figure 1 Preferred Reporting items for Systematic Reviews and Meta-analyses (PRISMA) flow diagram showing study selection. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

3 Figure 2 Group 3: Reduction in EAC-related mortality. M-H, Mantel-Haenszel risk ratio. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

4 Figure 3 Group 3: Reduction in all-cause mortality. GI, gastrointestinal; IV, instrumental variable; SE, standard error. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

5 Figure 4 Group 4: Reduction in EAC-related mortality. diag, diagnosis; M-H, Mantel-Haenszel risk ratio. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

6 Figure 5 All-cause mortality (with studies providing adjusted data). diag, diagnosis; GERD, gastroesophageal reflux disease; IV, instrumental variable; SE, standard error. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

7 Figure 6 Sensitivity analysis: Lead time–adjusted overall mortality in group 4. IV, instrumental variable; SE, standard error. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

8 Supplementary Figure 1 Group 3: Early Stage (Stage 0 and I) Diagnosis.
Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

9 Supplementary Figure 2 Group 3: Surgical Resection and Esophagectomy rates. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

10 Supplementary Figure 3 Group 4: Reduction in all-cause mortality (all studies included). Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

11 Supplementary Figure 4 Group 4: Funnel Plot of Group 4: Reduction in all-cause mortality. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

12 Supplementary Figure 5 Group 4: Early Stage (Stage 0 and I) Diagnosis.
Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

13 Supplementary Figure 6 Surgical Resection and Esophagectomy rates.
Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

14 Supplementary Figure 7 Sensitivity Analysis: Reduction in all-cause mortality in studies with pre-specified surveillance intervals. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

15 Supplementary Figure 8 Overall mortality in studies from the initiation of BE surveillance. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions

16 Supplementary Figure 9 EAC-related mortality in studies from the initiation of BE surveillance. Gastroenterology  , e5DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions


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