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Christopher Hine, James R. Mitchell  Cell Stem Cell 

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1 Saying No to Drugs: Fasting Protects Hematopoietic Stem Cells from Chemotherapy and Aging 
Christopher Hine, James R. Mitchell  Cell Stem Cell  Volume 14, Issue 6, Pages (June 2014) DOI: /j.stem Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Fasting Ameliorates Effects of Chemotherapy and Aging on Bone Marrow Prolonged fasting boosts bone marrow hematopoietic stem cell (HSC) self-renewal and increases resistance to chemotherapeutic toxicity and aging-related loss of homeostasis through decreased IGF-1/PKA signaling. This results in maintenance of lymphoid cell (LC) and myeloid cell (MC) numbers and ratios and improved immune function. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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