1. The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial 
Pierluigi Paggiaro, MD, David M.G. Halpin, FRCP, Roland Buhl, MD, PhD, Michael Engel, MD, Valentina B. Zubek, PhD, Zuzana Blahova, PharmDr, Petra Moroni-Zentgraf, MD, Emilio Pizzichini, DD, PhD 
The Journal of Allergy and Clinical Immunology: In Practice 
Volume 4, Issue 1, Pages e2 (January 2016)
DOI: /j.jaip
Copyright © 2015 The Authors Terms and Conditions

2. Figure 1 Patient disposition. AE, adverse event.
The Journal of Allergy and Clinical Immunology: In Practice 2016 4, e2DOI: ( /j.jaip )
Copyright © 2015 The Authors Terms and Conditions

3. Figure 2
Adjusted mean peak FEV1(0-3h) response over the 12-week study period. *P < .05; **P < Response defined as a difference from the baseline value at randomization. Error bars are ± standard error. Baseline mean (standard deviation) FEV1, mL, at visit 2: 2420 (711). Adjusted for treatment, center, visit, baseline, treatment-by-visit interaction, and baseline-by-visit interaction. FEV1, forced expiratory volume in 1 second; peak FEV1(0-3h), peak forced expiratory volume in 1 second within 3 hours of dosing.
The Journal of Allergy and Clinical Immunology: In Practice 2016 4, e2DOI: ( /j.jaip )
Copyright © 2015 The Authors Terms and Conditions

4. Figure 3
Adjusted mean weekly morning PEF (A) and adjusted mean weekly evening PEF (pre-bronchodilator) (B). P < .05 vs placebo for both tiotropium doses at all time points. Response defined as a difference from the baseline value at randomization. Error bars are ± standard error. Baseline mean (standard deviation) PEF, L/min, at visit 2: morning, (114.5); evening, (115.0). PEF, peak expiratory flow.
The Journal of Allergy and Clinical Immunology: In Practice 2016 4, e2DOI: ( /j.jaip )
Copyright © 2015 The Authors Terms and Conditions