1. Volume 9, Issue 8, Pages S3-S13 (August 2012)
Cardiac resynchronization therapy (CRT): Clinical trials, guidelines, and target populations 
Cecilia Linde, MD, PhD, Kenneth Ellenbogen, MD, FHRS, Finlay A. McAlister, MD 
Heart Rhythm 
Volume 9, Issue 8, Pages S3-S13 (August 2012)
DOI: /j.hrthm
Copyright © 2012 Heart Rhythm Society Terms and Conditions

2. Figure 1
Uncertainty of link between interventricular and intraventricular dyssynchrony, and QRS morphology. %DLC = extent of myocardium showing delayed longitudinal contraction; Inter-V = interventricular dyssynchrony; SD-12 = standard deviation of TP of the 12 left ventricular segments; TO-6base = maximal difference in TO between any two of six basal left ventricular segments; TP-6base = maximal difference in TP between any two of six basal segments; TP-sep-lat = difference between TP of septobasal and laterobasal segments.
Reproduced with permission from Ghio S, Constantin C, Klersy C, et al. Eur Heart J 2004.
Heart Rhythm 2012 9, S3-S13DOI: ( /j.hrthm )
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3. Figure 2
A: As shown in several clinical trials, for patients with moderate-to-severe heart failure (HF; New York Heart Association [NYHA] class III–IV), cardiac resynchronization therapy (CRT) provides very consistent improvements in NYHA functional class ranking, exercise capacity (measured by 6-minute hall walk distance), and peak oxygen consumption. B: As shown in several clinical trials, for patients with moderate-to-severe HF (NYHA class III–IV), CRT provides very consistent improvements in NYHA functional class ranking, exercise capacity (measured by 6-minute hall walk distance), and peak oxygen consumption.
Heart Rhythm 2012 9, S3-S13DOI: ( /j.hrthm )
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4. Figure 3
MADIT-CRT—significant reduction in relative risk of sustaining a primary endpoint with CRT-D. CRT = cardiac resynchronization therapy; HF = heart failure.
Adapted from Moss et al.20
Heart Rhythm 2012 9, S3-S13DOI: ( /j.hrthm )
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5. Figure 4
REVERSE—time to first hospitalization for management of congestive heart failure (HF) or to death from any cause was significantly delayed. CRT = cardiac resynchronization therapy.
Adapted from Linde et al.19
Heart Rhythm 2012 9, S3-S13DOI: ( /j.hrthm )
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6. Figure 5
RAFT—primary endpoint. CRT = cardiac resynchronization therapy; ICD = implantable cardioverter-defibrillator.
Adapted from Tang et al.21
Heart Rhythm 2012 9, S3-S13DOI: ( /j.hrthm )
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7. Figure 6
Composite clinical score from MIRACLE-ICD II. CRT = cardiac resynchronization therapy.
Adapted from Abraham et al.14
Heart Rhythm 2012 9, S3-S13DOI: ( /j.hrthm )
Copyright © 2012 Heart Rhythm Society Terms and Conditions

8. Figure 7 Composite clinical score from PROSPECT.
Adapted from Chung et al.33
Heart Rhythm 2012 9, S3-S13DOI: ( /j.hrthm )
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