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Thoughts on Obesity and Brain Glucose

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Presentation on theme: "Thoughts on Obesity and Brain Glucose"— Presentation transcript:

1 Thoughts on Obesity and Brain Glucose
Michael T. Heneka, Pierluigi Nicotera  Cell  Volume 165, Issue 4, Pages (May 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 High-Fat Diet Stimulates a Brain-Driven Homeostatic Response
(A) VEGF restores activity of the glucose transporter Glut-1, previously downregulated by the high-fat diet (HFD) (most likely by saturated fatty acids [SFA]). (B) The homeostatic restoration of brain glucose uptake is abolished if macrophages are VEGF deficient. (C) VEGF deficiency exacerbates cognitive defects in mouse models of Amyloid β deposition (APP/PS1). Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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