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Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age  Jintanat Ananworanich,

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Presentation on theme: "Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age  Jintanat Ananworanich,"— Presentation transcript:

1 Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age  Jintanat Ananworanich, MD, PhD, Tanakorn Apornpong, MSc, Pope Kosalaraksa, MD, Tanyathip Jaimulwong, BSc, Rawiwan Hansudewechakul, MD, Chitsanu Pancharoen, MD, Torsak Bunupuradah, MD, Mom Chandara, MSc, Thanyawee Puthanakit, MD, Chaiwat Ngampiyasakul, MD, Jurai Wongsawat, MD, Suparat Kanjanavanit, MD, Wicharn Luesomboon, MD, Phennapha Klangsinsirikul, PhD, Nicole Ngo-Giang-Huong, PharmD, PhD, Stephen J. Kerr, PhD, Sasiwimol Ubolyam, MSc, Tawan Mengthaisong, RN, Rebecca S. Gelman, PhD, Kovit Pattanapanyasat, PhD, Vonthanak Saphonn, MD, PhD, Kiat Ruxrungtham, MD, MSc, William T. Shearer, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 126, Issue 6, Pages e10 (December 2010) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Comparison of cell subsets among 4 age groups of HIV-positive and healthy children. A, CD45+/CD3+/CD19− (total T cells). B, CD45+/CD3+/CD4+ (TH cells). C, CD45+/CD3+/CD8+ (cytotoxic T cells). D, CD45+/CD3−/CD19+ (B cells). E, CD45+/CD3−/CD16+/CD56+ (NK cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 1 Comparison of cell subsets among 4 age groups of HIV-positive and healthy children. A, CD45+/CD3+/CD19− (total T cells). B, CD45+/CD3+/CD4+ (TH cells). C, CD45+/CD3+/CD8+ (cytotoxic T cells). D, CD45+/CD3−/CD19+ (B cells). E, CD45+/CD3−/CD16+/CD56+ (NK cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 1 Comparison of cell subsets among 4 age groups of HIV-positive and healthy children. A, CD45+/CD3+/CD19− (total T cells). B, CD45+/CD3+/CD4+ (TH cells). C, CD45+/CD3+/CD8+ (cytotoxic T cells). D, CD45+/CD3−/CD19+ (B cells). E, CD45+/CD3−/CD16+/CD56+ (NK cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Comparison of cell subsets between HIV-positive and healthy children for 4 age groups. CD4+/45RA+/62L+ (naive TH cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Comparison of cell subsets between HIV-positive and healthy children for 4 age groups. CD3+/4+/45RO+ (memory TH cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Comparison of cell subsets between HIV-positive and healthy children for 4 age groups. CD4+/DR+/38+ (activated TH cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Comparison of cell subsets between HIV-positive and healthy children for 4 age groups. CD8+/45RA+/62L+ (naive cytotoxic T cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Comparison of cell subsets between HIV-positive and healthy children for 4 age groups. CD3+/4-/45RO+ (memory cytotoxic T cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Comparison of cell subsets between HIV-positive and healthy children for 4 age groups. CD8+/DR+/38+ (activated cytotoxic T cells). ∗P < .05. No. of children: <2 to 3 years (n = 79), 4 to 5 years (n = 74), 6 to 8 years (n = 135), 9 to 12 years (n = 76). Pos, Positive. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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