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The Microbiome of the Prostate Tumor Microenvironment

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1 The Microbiome of the Prostate Tumor Microenvironment
Ilaria Cavarretta, Roberto Ferrarese, Walter Cazzaniga, Diego Saita, Roberta Lucianò, Elisa R. Ceresola, Irene Locatelli, Laura Visconti, Giovanni Lavorgna, Alberto Briganti, Manuela Nebuloni, Claudio Doglioni, Massimo Clementi, Francesco Montorsi, Filippo Canducci, Andrea Salonia  European Urology  Volume 72, Issue 4, Pages (October 2017) DOI: /j.eururo Copyright © 2017 European Association of Urology Terms and Conditions

2 Fig. 1 Bacterial average relative abundance in prostate tumor (T), peri-tumor (PT), and nontumor (NT) samples. Average distribution of major taxa is represented by bar graphs (A) phylum, (B) class, (C) order, (D) family, (E) genus. European Urology  , DOI: ( /j.eururo ) Copyright © 2017 European Association of Urology Terms and Conditions

3 Fig. 2 Beta diversity analysis. Principal component (PC) analysis plot of weighted UniFrac metrics for tumor (yellow dots), peri-tumor (blue dots), and nontumor (red dots) areas of prostate samples. Multivariate analysis shows that the microbiome of the prostate is similar among the patients and that the samples from the three prostate areas do not cluster by their overall microbiome composition. However, for some patients, nontumoral areas appear distant from the tumor and peri-tumor samples. European Urology  , DOI: ( /j.eururo ) Copyright © 2017 European Association of Urology Terms and Conditions


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