Presentation is loading. Please wait.

Presentation is loading. Please wait.

Mark S. Forman, Virginia M-Y. Lee, John Q. Trojanowski  Neuron 

Published byClarence Spencer Modified over 6 years ago

Similar presentations

Presentation on theme: "Mark S. Forman, Virginia M-Y. Lee, John Q. Trojanowski  Neuron "— Presentation transcript:

1 Nosology of Parkinson’s Disease: Looking for the Way Out of a Quackmire 
Mark S. Forman, Virginia M-Y. Lee, John Q. Trojanowski  Neuron  Volume 47, Issue 4, Pages (August 2005) DOI: /j.neuron Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Molecular Genetic Neuropathology of Parkinson’s Disease
Algorithm for the neuropathologic differential diagnosis of patients with PD. Neuropathologic examination of the majority of patients with L-dopa-responsive parkinsonism reveals α-synuclein-positive Lewy body pathology (indicated in blue). However, neuropathologic evaluation cannot readily distinguish those patients with concurrent dementia (i.e., PDD or DLB). In addition, a subset of parkinsonian patients will have α-synuclein-positive glial cytoplasmic inclusions indicative of multiple system atrophy while other patients will have tau pathology (±senile plaques). There is limited neuropathologic data on patients with many of the newly described mutations. Moreover, this algorithm represents an oversimplification and does not reflect other disorders that may also present with parkinsonism. AD, Alzheimer’s disease; CBD, corticobasal degeneration; DLB, dementia with Lewy bodies; FTDP-17, frontotemporal dementia with parkinsonism linked to chromosome 17; GCI, glial cytoplasmic inclusions; LBVAD, Lewy body variant of Alzheimer’s disease; MSA, multiple system atrophy; PD, Parkinson’s disease; PDD, Parkinson’s disease dementia; PSP, progressive supranuclear palsy. Neuron  , DOI: ( /j.neuron ) Copyright © 2005 Elsevier Inc. Terms and Conditions

Download ppt "Mark S. Forman, Virginia M-Y. Lee, John Q. Trojanowski  Neuron "

Similar presentations

Synucleinopathies and Tauopathies

Synucleinopathies and Tauopathies
The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages 733-745 (September 2009) DOI:

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:
CSF tau Is it an informative biomarker of AD pathology Chris Clark Alzheimer’s Disease Center University of Pennsylvania.

CSF tau Is it an informative biomarker of AD pathology Chris Clark Alzheimer’s Disease Center University of Pennsylvania.
Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.
A 67-year-old male with behavioral and language problems

A 67-year-old male with behavioral and language problems
Parkinson’s Plus By: Glen Estrosos.

Parkinson’s Plus By: Glen Estrosos.
Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.
The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages 844-866 (November 2013) DOI: 10.1016/j.neuron.2013.10.008 Copyright.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.
Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages 791-806 (October 2013) DOI: 10.1016/j.neuron.2013.10.047.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron
Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages 951-962 (June 2006) DOI: 10.1016/j.neuron.2006.04.035.

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages 1262-1272 (September 2014)

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Multiscale Optical Ca2+ Imaging of Tonal Organization in Mouse Auditory Cortex John B. Issa, Benjamin D. Haeffele, Amit Agarwal, Dwight E. Bergles, Eric.

Multiscale Optical Ca2+ Imaging of Tonal Organization in Mouse Auditory Cortex John B. Issa, Benjamin D. Haeffele, Amit Agarwal, Dwight E. Bergles, Eric.
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.
Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes John H. Lee, Luis Tecedor, Yong Hong Chen, Alex Mas Monteys,

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes John H. Lee, Luis Tecedor, Yong Hong Chen, Alex Mas Monteys,
Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages 333-338 (February 2008) DOI: 10.1016/j.neuron.2008.01.018.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron
Biomarkers of Alzheimer’s Disease. Objectively mark Presence of neurodegenerative pathology Change in pathologic activity Purpose.

Biomarkers of Alzheimer’s Disease. Objectively mark Presence of neurodegenerative pathology Change in pathologic activity Purpose.
Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.
CPC #7: Pathology Barbara J. Crain, MD, PhD February 25, 2009.

CPC #7: Pathology Barbara J. Crain, MD, PhD February 25, 2009.
Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others Jason P. Mitchell, C. Neil Macrae, Mahzarin R. Banaji Neuron.

Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others Jason P. Mitchell, C. Neil Macrae, Mahzarin R. Banaji Neuron.
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages 332-384 (March.

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Similar presentations

Ads by Google