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Michael W.M. Kühn, Scott A. Armstrong  Cancer Cell 

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Presentation on theme: "Michael W.M. Kühn, Scott A. Armstrong  Cancer Cell "— Presentation transcript:

1 Designed to Kill: Novel Menin-MLL Inhibitors Target MLL-Rearranged Leukemia 
Michael W.M. Kühn, Scott A. Armstrong  Cancer Cell  Volume 27, Issue 4, Pages (April 2015) DOI: /j.ccell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Inhibiting the Menin-MLL Interaction Causes Hox Gene Downregulation and Differentiation of MLL-Rearranged Leukemia (A) The menin-MLL interaction is required for Hox gene expression that is critical for MLL-rearranged leukemia. (B) Small-molecule MI-463 and MI-503 block the MLL binding site on menin, resulting in downregulation of Hox genes and differentiation of leukemic blasts. Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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