Presentation is loading. Please wait.

Presentation is loading. Please wait.

Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite–sensitive patients with asthma  Kittipong Maneechotesuwan, MD,

Published byMarino Marinelli Modified over 6 years ago

Similar presentations

Presentation on theme: "Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite–sensitive patients with asthma  Kittipong Maneechotesuwan, MD,"— Presentation transcript:

1 Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite–sensitive patients with asthma  Kittipong Maneechotesuwan, MD, PhD, Valla Wamanuttajinda, BSc, Kanda Kasetsinsombat, MSc, Sukit Huabprasert, BA, Metha Yaikwawong, MD, Peter J. Barnes, DM, FRS, Adisak Wongkajornsilp, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 123, Issue 1, Pages (January 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Differential effect of Der p 1 on the expression and activity (A and B) of IDO in DCs. Protein levels of IDO (C and E), surface molecules, and intracellular cytokines (D) in DCs and TNF receptors on monocytes (F) were analyzed by fluorescence-activated cell sorting. One representative experiment of 3 is shown. Results are expressed as the means ± SDs. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 1 Differential effect of Der p 1 on the expression and activity (A and B) of IDO in DCs. Protein levels of IDO (C and E), surface molecules, and intracellular cytokines (D) in DCs and TNF receptors on monocytes (F) were analyzed by fluorescence-activated cell sorting. One representative experiment of 3 is shown. Results are expressed as the means ± SDs. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 1 Differential effect of Der p 1 on the expression and activity (A and B) of IDO in DCs. Protein levels of IDO (C and E), surface molecules, and intracellular cytokines (D) in DCs and TNF receptors on monocytes (F) were analyzed by fluorescence-activated cell sorting. One representative experiment of 3 is shown. Results are expressed as the means ± SDs. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 1 Differential effect of Der p 1 on the expression and activity (A and B) of IDO in DCs. Protein levels of IDO (C and E), surface molecules, and intracellular cytokines (D) in DCs and TNF receptors on monocytes (F) were analyzed by fluorescence-activated cell sorting. One representative experiment of 3 is shown. Results are expressed as the means ± SDs. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 2 Proliferative response of allergen-specific T-cell clones to Der p 1–pulsed DCs or their conditioned medium from HDM-sensitive, nonatopic patients with asthma and normal subjects (A), and to Der p 1–pulsed DCs or their conditioned medium from multiallergic subjects and subjects with cockroach allergy (B). Means ± SDs of 3 independent experiments are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 3 TH1/TH2 cytokine profiles (A and B) maintained IDO activity (C) and clonal T-cell proliferation (D) in HDM-sensitive and nonatopic DCs. An increase in regulatory T-cell subset (E) and its activity (F) was observed in the nonatopic condition. Means ± SDs of 3 independent experiments are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig 4 Neutralization study using mAbs revealed the regulation of IDO activity in DCs was mediated through IL-4 and IFN-γ (A and B) with a corresponding action on clonal T-cell proliferation (C and D). Means ± SDs of 3 independent experiments are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig 5 Differential regulation of IDO by Der p 1 in DCs based on HDM sensitivity was mediated through IL-4, IFN-γ, and the regulatory T-cell subset. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite–sensitive patients with asthma  Kittipong Maneechotesuwan, MD,"

Similar presentations

Dorothea Dijkstra, MSc, Rob Leurs, PhD, Paul Chazot, PhD, Fiona C

Dorothea Dijkstra, MSc, Rob Leurs, PhD, Paul Chazot, PhD, Fiona C
Doina M. Racila, MD, Joel N. Kline, MD, MSc 

Doina M. Racila, MD, Joel N. Kline, MD, MSc 
Volume 148, Issue 5, Pages (November 2015)

Volume 148, Issue 5, Pages (November 2015)
Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a “proallergic” milieu  Amanda J. Reefer, MS, Kathryn.

Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a “proallergic” milieu  Amanda J. Reefer, MS, Kathryn.
Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy  Yin Yao, MD, Cai-Ling.

Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy  Yin Yao, MD, Cai-Ling.
Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites 

Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites 
CD39: A new surface marker of mouse regulatory γδ T cells

CD39: A new surface marker of mouse regulatory γδ T cells
Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells  Marc A. Williams,

Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells  Marc A. Williams,
Advances in food allergy in 2015

Advances in food allergy in 2015
Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance  Margot Berings, MD, Cagatay Karaaslan,

Advances and highlights in allergen immunotherapy: On the way to sustained clinical and immunologic tolerance  Margot Berings, MD, Cagatay Karaaslan,
Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis  Eva Gros, MSc, Susanne Petzold,

Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis  Eva Gros, MSc, Susanne Petzold,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
The role of viruses in acute exacerbations of asthma

The role of viruses in acute exacerbations of asthma
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life?  Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life?  Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.
Prostaglandin E2 suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes  Naoko Kanda, MD, PhD, Hiroshi Mitsui, MD, PhD, Shinichi.

Prostaglandin E2 suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes  Naoko Kanda, MD, PhD, Hiroshi Mitsui, MD, PhD, Shinichi.
Toll-like receptor 7–induced naive human B-cell differentiation and immunoglobulin production  Mark C. Glaum, MD, PhD, Shilpi Narula, MD, Decheng Song,

Toll-like receptor 7–induced naive human B-cell differentiation and immunoglobulin production  Mark C. Glaum, MD, PhD, Shilpi Narula, MD, Decheng Song,
Regulation of TH17 cells in the mucosal surfaces

Regulation of TH17 cells in the mucosal surfaces
Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization  Silvia.

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization  Silvia.
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?

Similar presentations

Ads by Google