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Injectable Options as Add-Ons to Basal Insulin: Targeting PPG in Type 2 Diabetes Patients.

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Presentation on theme: "Injectable Options as Add-Ons to Basal Insulin: Targeting PPG in Type 2 Diabetes Patients."— Presentation transcript:

1 Injectable Options as Add-Ons to Basal Insulin: Targeting PPG in Type 2 Diabetes Patients

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3 Program Goals

4 The Incretin System: Response to Oral Glucose

5 Injected Incretin-based Agents: GLP-1 Receptor Agonists

6 Oral Incretin-based Agents: DPP-4 Inhibitors

7 Main Pathophysiological Defects in T2D

8 T2D Anti-Hyperglycemic Therapy: General Recommendations

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10 Approaches to Intensifying Therapy in Patients Not At Goal on Basal Insulin

11 Adding Prandial Insulin to Basal Insulin: Key Challenges

12 Scientific Rationale for Combining Basal Insulin with a GLP-1 agonist

13 DPP- 4 Inhibitors as Add-ons to Basal Insulin

14 Pramlintide as Add-on to Basal Insulin

15 Twice-daily Exenatide as Add-on to Basal Insulin (Glargine)

16 Twice-daily Exenatide as Add-on to Basal Insulin (Glargine): Results

17 Metformin plus Liraglutide Followed by Add-on of Basal Insulin (Detemir)

18 Metformin plus Liraglutide Followed by Add-on of Basal Insulin (Detemir)

19 Oral Agents Plus Basal Insulin (Glargine) Followed by Add-on Lixisenatide*

20 Oral Agents Plus Basal Insulin (Glargine) Followed by Add-on Lixisenatide* (cont)

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22 Other Safety Concerns With GLP-1 Receptor Agonists

23 Lixisenatide* vs Liraglutide: Effect on Postprandial Glucose Levels†

24 Comparison of Basal Insulin + Lixisenatide* and Basal-Plus Regimensa

25 IDegLira* vs Degludec* or Liraglutide Alone: Effect on HbA1c

26 IDegLira* vs Degludec* or Liraglutide Alone: Results

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28 Abbreviations

29 Abbreviations (cont)

30 References

31 References (cont)

32 References (cont)

33 References (cont)

34 References (cont)

35 References (cont)

36 References (cont)

37 References (cont)

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41 References (cont)


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