1. Monitoring plasma concentrations to individualize treatment with clomiphene citrate 
Amin Rostami-Hodjegan, Ph.D., Martin S Lennard, Ph.D., Geoffrey T Tucker, Ph.D., William L Ledger, D.Phil. 
Fertility and Sterility 
Volume 81, Issue 5, Pages (May 2004)
DOI: /j.fertnstert

2. FIGURE 1
Schematic representation of the algorithm used currently for dose adjustment in the treatment of infertile women with clomiphene.
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

3. FIGURE 2
Quantal dose–response relationship for clomiphene. The size of the data points reflects the relative number of patients in each study. The solid line is the best fit to weighted data by meta-analysis. Key: Imani et al (2) (n = 201); Gysler et al (3) (n = 428); · Canales et al (4) (n = 22); Boostanfar et al (5) (n = 40); ■--- Drake et al (6) (n = 45); □ van Zonneveld et al (7) (n = 24); ♦ March et al (8) (n = 138); ♢ Rudolf et al 1983 (9) (n = 482); ♦--- Prough et al (10) (n = 18); Hammond and Talbert 1982 (11) (n = 61); ▴--- Gorlitsky et al (12) (n = 62); Shepard et al (13) (n = 62); × Lobo et al (14) (n = 57).
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

4. FIGURE 2
Quantal dose–response relationship for clomiphene. The size of the data points reflects the relative number of patients in each study. The solid line is the best fit to weighted data by meta-analysis. Key: Imani et al (2) (n = 201); Gysler et al (3) (n = 428); · Canales et al (4) (n = 22); Boostanfar et al (5) (n = 40); ■--- Drake et al (6) (n = 45); □ van Zonneveld et al (7) (n = 24); ♦ March et al (8) (n = 138); ♢ Rudolf et al 1983 (9) (n = 482); ♦--- Prough et al (10) (n = 18); Hammond and Talbert 1982 (11) (n = 61); ▴--- Gorlitsky et al (12) (n = 62); Shepard et al (13) (n = 62); × Lobo et al (14) (n = 57).
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

5. FIGURE 2
Quantal dose–response relationship for clomiphene. The size of the data points reflects the relative number of patients in each study. The solid line is the best fit to weighted data by meta-analysis. Key: Imani et al (2) (n = 201); Gysler et al (3) (n = 428); · Canales et al (4) (n = 22); Boostanfar et al (5) (n = 40); ■--- Drake et al (6) (n = 45); □ van Zonneveld et al (7) (n = 24); ♦ March et al (8) (n = 138); ♢ Rudolf et al 1983 (9) (n = 482); ♦--- Prough et al (10) (n = 18); Hammond and Talbert 1982 (11) (n = 61); ▴--- Gorlitsky et al (12) (n = 62); Shepard et al (13) (n = 62); × Lobo et al (14) (n = 57).
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

6. FIGURE 2
Quantal dose–response relationship for clomiphene. The size of the data points reflects the relative number of patients in each study. The solid line is the best fit to weighted data by meta-analysis. Key: Imani et al (2) (n = 201); Gysler et al (3) (n = 428); · Canales et al (4) (n = 22); Boostanfar et al (5) (n = 40); ■--- Drake et al (6) (n = 45); □ van Zonneveld et al (7) (n = 24); ♦ March et al (8) (n = 138); ♢ Rudolf et al 1983 (9) (n = 482); ♦--- Prough et al (10) (n = 18); Hammond and Talbert 1982 (11) (n = 61); ▴--- Gorlitsky et al (12) (n = 62); Shepard et al (13) (n = 62); × Lobo et al (14) (n = 57).
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

7. FIGURE 2
Quantal dose–response relationship for clomiphene. The size of the data points reflects the relative number of patients in each study. The solid line is the best fit to weighted data by meta-analysis. Key: Imani et al (2) (n = 201); Gysler et al (3) (n = 428); · Canales et al (4) (n = 22); Boostanfar et al (5) (n = 40); ■--- Drake et al (6) (n = 45); □ van Zonneveld et al (7) (n = 24); ♦ March et al (8) (n = 138); ♢ Rudolf et al 1983 (9) (n = 482); ♦--- Prough et al (10) (n = 18); Hammond and Talbert 1982 (11) (n = 61); ▴--- Gorlitsky et al (12) (n = 62); Shepard et al (13) (n = 62); × Lobo et al (14) (n = 57).
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

8. FIGURE 2
Quantal dose–response relationship for clomiphene. The size of the data points reflects the relative number of patients in each study. The solid line is the best fit to weighted data by meta-analysis. Key: Imani et al (2) (n = 201); Gysler et al (3) (n = 428); · Canales et al (4) (n = 22); Boostanfar et al (5) (n = 40); ■--- Drake et al (6) (n = 45); □ van Zonneveld et al (7) (n = 24); ♦ March et al (8) (n = 138); ♢ Rudolf et al 1983 (9) (n = 482); ♦--- Prough et al (10) (n = 18); Hammond and Talbert 1982 (11) (n = 61); ▴--- Gorlitsky et al (12) (n = 62); Shepard et al (13) (n = 62); × Lobo et al (14) (n = 57).
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

9. Fertility and Sterility 2004 81, 1187-1193DOI: (10. 1016/j. fertnstert

10. Fertility and Sterility 2004 81, 1187-1193DOI: (10. 1016/j. fertnstert

11. Fertility and Sterility 2004 81, 1187-1193DOI: (10. 1016/j. fertnstert

12. Fertility and Sterility 2004 81, 1187-1193DOI: (10. 1016/j. fertnstert

13. Fertility and Sterility 2004 81, 1187-1193DOI: (10. 1016/j. fertnstert

14. FIGURE 3
Illustration of the complex interplay between processes (boxes framed with broken lines) that might be subject to wide interindividual differences (genetic or environmental) leading to different concentrations of active moiety(/ies) at effect sites after similar clomiphene dose intake in different patients.
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

15. FIGURE 4
Inter- and intraindividual variability in the plasma emclomiphene/zuclomiphen ratio in women undergoing clomiphene therapy. All bars represent ratios from trough concentrations taken during multiple-dose administration of clomiphene.
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

16. FIGURE 5
Plasma zuclomiphene concentrations in three patients who received different doses of clomiphene citrate (for 5 days, starting on the 2nd day of each ovulation cycle). (A) The patient received 50 mg/day during each cycle, ovulated in the first cycle, and conceived in the third cycle. (B) The patient received 50 mg/day during the first cycle, 100 mg/day during the second and third cycles, and ovulated in the second cycle. (C) The patient received 50 mg/day during the first cycle, 100 mg/day during the second cycle, and 150 mg/day during the third cycle, but did not ovulate during the study. Vertical lines indicate the beginning of each cycle.
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )

17. FIGURE 6
An algorithm for dose adjustment based on the measurement of plasma clomiphene concentrations in infertile women treated with clomiphene citrate.
Rostami-Hodjegan. Clomiphene dose individualization. Fertil Steril 2004.
Fertility and Sterility  , DOI: ( /j.fertnstert )