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Published byBrigitta Simons Modified over 6 years ago
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Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue
Marie-Madeleine Dolmans, M.D., Ph.D., Valérie Luyckx, M.D., Jacques Donnez, M.D., Ph.D., Claus Yding Andersen, D.M.Sc., Tine Greve, M.D. Fertility and Sterility Volume 99, Issue 6, Pages (May 2013) DOI: /j.fertnstert Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Histologic analysis of an ovarian fragment recovered from a mouse after 6 months' grafting (acute lymphoblastic leukemia patients). A human follicle is encircled by a large number of lymphocytes. Normal ovarian stroma is no longer present. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Ovarian fragments from a non-Hodgkin lymphoma (NHL) patient. (A) Immunohistochemistry anti-CD20 (against NHL cells) is negative in the cortex (blue staining) and positive in the medulla (brown staining). Magnification of the white rectangle is represented in (B) and magnification of the black rectangle in (C). (B) Cells with an enlarged nucleus and patchy chromatin are disseminated in the tissue and stain strongly for anti-CD20. (C) Piece of cancer cell-free cortex. Follicles present in the cortex appear healthy. (D) Another fragment from the same patient shows massive invasion by NHL cells in the cortex. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions
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