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Dissecting the Dynamics of Corticothalamic Feedback

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1 Dissecting the Dynamics of Corticothalamic Feedback
Henry J. Alitto, W. Martin Usrey  Neuron  Volume 86, Issue 3, Pages (May 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Corticothalamic Circuitry for the Visual, Auditory, and Somatosensory Systems All three systems share a similar basic organization. Thalamocortical projections arise from relay neurons located in the LGN, MGB, and VPM that provide input to primary visual, auditory, and somatosensory cortex, respectively. Neurons in cortical layer 6, in turn, give rise to feedback projections to the thalamus. Corticothalamic feedback axons influence relay cell activity via monosynaptic and disynaptic connections. The monosynaptic pathway is excitatory and uses glutamatergic synapses, whereas the disynaptic pathway involves a collateral projection into the TRN that excites GABAergic neurons that, in turn, provide inhibitory input onto relay neurons. Neuron  , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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