Presentation is loading. Please wait.

Presentation is loading. Please wait.

Three Rules for HIV Latency: Location, Location, and Location

Published byἈράχνη Νικολάκος Modified over 6 years ago

Similar presentations

Presentation on theme: "Three Rules for HIV Latency: Location, Location, and Location"— Presentation transcript:

1 Three Rules for HIV Latency: Location, Location, and Location
Melanie Ott, Eric Verdin  Cell Host & Microbe  Volume 13, Issue 6, Pages (June 2013) DOI: /j.chom Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Regulation of HIV Latency by Proximity to the PML Nuclear Body Under latency conditions, the HIV provirus is positioned in close proximity to PML nuclear bodies. PML recruits the methyltransferase G9a to the HIV promoter, leading to dimethylation of lysine 9 in histone H3 and transcriptional silencing. Upon treatment with the phorbol ester TPA, the deacetylase inhibitor SAHA, or arsenic trioxide, a compound inducing PML degradation, the HIV provirus is relocated away from PML nuclear bodies, and HIV transcription is activated. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2013 Elsevier Inc. Terms and Conditions

Download ppt "Three Rules for HIV Latency: Location, Location, and Location"

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages 20-44 (January 2014) DOI: 10.1016/j.cell.2013.12.012.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut Patrick H. Degnan, Natasha A. Barry, Kenny C. Mok,

Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut Patrick H. Degnan, Natasha A. Barry, Kenny C. Mok,
An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans Amy G. Hise, Jeffrey Tomalka, Sandhya Ganesan,

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans Amy G. Hise, Jeffrey Tomalka, Sandhya Ganesan,
Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription Chia-Hsin.

Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription Chia-Hsin.
Genes Induced Late in Infection Increase Fitness of Vibrio cholerae after Release into the Environment Stefan Schild, Rita Tamayo, Eric J. Nelson, Firdausi.

Genes Induced Late in Infection Increase Fitness of Vibrio cholerae after Release into the Environment Stefan Schild, Rita Tamayo, Eric J. Nelson, Firdausi.
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages 255-266 (March 2014) DOI: 10.1016/j.cell.2014.03.012.

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages 248-252 (April 2010) DOI: 10.1016/j.cmet.2010.03.008 Copyright © 2010.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.

A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.
SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.

SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.
CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages 159-169.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages 838-850 (June 2013) DOI:

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming Smita Srivastava, Joel D. Ernst Cell Host & Microbe Volume 15, Issue 6,

Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming Smita Srivastava, Joel D. Ernst Cell Host & Microbe Volume 15, Issue 6,
Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7 Hyun.

Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7 Hyun.
Trained Immunity: An Ancient Way of Remembering

Trained Immunity: An Ancient Way of Remembering
Something Old, Something New, Something Borrowed …

Something Old, Something New, Something Borrowed …
Targeting Epigenetics to Speed Up Repair

Targeting Epigenetics to Speed Up Repair
Volume 1, Issue 1, Pages (June 2007)

Volume 1, Issue 1, Pages (June 2007)
P Bodies, Stress Granules, and Viral Life Cycles

P Bodies, Stress Granules, and Viral Life Cycles
A Way to DAI Cell Host & Microbe

A Way to DAI Cell Host & Microbe

Similar presentations

Ads by Google