1. Managing Diabetes condition with “Ginger” Supplements
Herbert Jelinek1,4, Wei Xu2, Patrick Ball2,
Tony Sahama3 and Andrew Stranieri4
1 School of Community Health, Charles Sturt University (CSU), NSW,
2 Discipline of Pharmacy, School of Biomedical Science, CSU, Wagga Wagga, NSW
3 School of Electrical Engineering & Computer Science, QUT, Brisbane
4 Centre for Informatics and Applied Optimisation, School of Science,
Information Technology & Engineering, University of Ballarat, Melbourne, Vic

2. Background (what is it?)
Diabetes is a silent killer
Impact is significant (Cost and Quality of Life)
Financial cost of type-2 diabetes is around $11billion
Around 300 Australians develop diabetes per day
Around 2 million Australians have diabetes: 50% type-2
~ 50% type-2 are undiagnosed ? (Diabetes Australia 2008)
There is no cure for type-1 and type-2 diabetes
The disease must be managed with
lifestyle
regular blood glucose testing
Mediation when required through clinical intervention
Clinical management of patient with
chronic diseases management processes and protocols
alternative approaches (e.g., elevation of antioxidants …….,)
Clinical validation and scientific experiments……..,
31/12/2018
Jelinek et al ICHM2012

3. Materials & Methods (How did we approach the problem?)
A controlled crossover study
A randomised control trail – (30 volunteers: 18 males + 12 females)
Participants (type -2 , 14 participants 10 males + 4 females)
The control group of 16 participants
Randomisation (Group A and B of each comprise 15 participants)
The treatment: Ginger root powder capsule (1000mg) daily for 4 weeks
Before the treatments:
Reference blood samples was taken
Oxidative biomarkers and Lipid profile were measured (GSM, MDA, LDL, HDL)
Group A: gets the treatments while Group B: Vitamin B1 100mg tablet daily (placebo)
After 4 weeks second blood sample was taken
oxidative biomarkers and lipid profile were measured and compared with initial readings
groups cross over  then repeated with Group A
after 4 weeks the third blood sample was taken
Statistical Analysis (Hypothesis Testing)
Two-sample t-test (P<0.05; CI=95%) and more …..? May be Factorial Experiments?
Repeat the experiments
Clinical validation and scientific experiments……..,
31/12/2018
Jelinek et al ICHM2012

4. What we achieved so far? Non-diabetic group had lower BMI
waist circumference
higher total cholesterol, LDL, HDL
Type-2 diabetic group (after Ginger treatment)
GSH value decreased significantly (P<0.034)
No difference for MDA & Methaemoglobin
With Vitamin B1 treatment, there is no differences were found for GSH, MDA and Methaemoglobin in either group
31/12/2018
Jelinek et al ICHM2012

5. How close are we?
31/12/2018
Jelinek et al ICHM2012

6. How close are we?
31/12/2018
Jelinek et al ICHM2012

7. How close are we?
31/12/2018
Jelinek et al ICHM2012

8. What we can say about it? Direct measurements In-direct measurements
Self-managing type-2 candidates
more accurate and faster diagnosis
reduction of early clinical time intervals
Reduction in BMI cholesterol- LDL, HDL
In-direct measurements
Reduction in GSH in the type-2 group
Ginger may have an antioxidant effect
Likelihood of reducing the diabetic….??
31/12/2018
Jelinek et al ICHM2012