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Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3  Se Jin Park,

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Presentation on theme: "Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3  Se Jin Park,"— Presentation transcript:

1 Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3  Se Jin Park, MD, Tae Hoon Kim, MD, Young Joon Jun, MD, Seung Hoon Lee, MD, Hyei Yul Ryu, MD, Kwang Jin Jung, MD, Jong Yoon Jung, MD, Gyu Ho Hwang, MD, Sang Hag Lee, MD  Journal of Allergy and Clinical Immunology  Volume 131, Issue 3, Pages (March 2013) DOI: /j.jaci Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Real-time PCR (A) and Western blot analysis (B) of SOCS1 and SOCS3 expression in normal and inflammatory sinus mucosa of CRSwNP and CRSsNP. Asterisk indicates significant difference in the expression levels of SOCS1 and SOCS3 between normal control and CRSwNP or CRSsNP (P < .05). White bar denotes SOCS1, and black bar indicates SOCS3. Results are expressed as mean ± SD. The panels of Western blot show representative data. C, Immunohistochemical localization of SOCS1 (1, 2, 3) and SOCS3 (4, 5, 6) in normal (1, 4) and inflammatory sinus mucosa of CRSwNP (2, 5) and CRSsNP (3, 6). In normal and inflammatory sinus mucosa, SOCS1 and SOCS3 were detected in the surface epithelium (arrowhead), submucosal glands (thick arrow), and vascular endothelium (thin arrow). Original magnification ×100. GAPDH, Glyceraldehyde-3-phosphate dehydrogenase. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Real-time PCR (A) and Western blot analysis (B) of IL-4, IL-5, IL-6, IL-10, IL-13, IFN-γ, TNF-α, and TGF-β1 expression levels in normal and inflammatory sinus mucosa of CRSwNP and CRSsNP. Black bar indicates normal sinus mucosa (n = 25), white bar indicates CRSwNP (n = 25), and gray bar represents CRSsNP (n = 25). Results are expressed as mean ± SD. The panels of Western blot show representative data. Asterisk indicates statistically significant difference in the expression levels of each cytokine among normal and inflammatory sinus mucosa of CRSwNP and CRSsNP (P < .05). GAPDH, Glyceraldehyde-3-phosphate dehydrogenase. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Real-time PCR (A, B) and Western blot analysis (C, D) of SOCS1 expression levels in cultured epithelial cells derived from normal (A, C) and inflammatory sinus mucosa (B, D) after stimulation with IL-4, IL-5, IL-6, IL-10, IL-13, IFN-γ, TNF-α, and TGF-β1, respectively, for 12 hours or 24 hours. Black bar indicates stimulation for 12 hours (n = 6), and white bar indicates stimulation for 24 hours (n = 6). Results are expressed as mean ± SD. The panels of Western blot show representative data of cultured normal epithelial cells. Asterisk indicates statistically significant difference in SOCS1 expression levels. GAPDH, Glyceraldehyde-3-phosphate dehydrogenase. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Real-time PCR (A, B) and Western blot analysis (C, D) of SOCS3 expression levels in cultured epithelial cells derived from normal (A, C) and inflammatory sinus mucosa (B, D) after stimulation with IL-4, IL-5, IL-6, IL-10, IL-13, IFN-γ, TNF-α, and TGF-β1, respectively, for 12 hours or 24 hours. Black bar indicates stimulation for 12 hours (n = 6), and white bar indicates stimulation for 24 hours (n = 6). Results are expressed as mean ± SD. The panels of Western blot show representative data of cultured normal epithelial cells. Asterisk indicates statistically significant difference in SOCS3 expression levels. GAPDH, Glyceraldehyde-3-phosphate dehydrogenase. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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