1. Perspectives on the Impact of Inflammation in OA

3. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States.

4. Introduction

5. Pathologic Changes in OA Joints

6. Role of Proinflammatory Cytokines in the Pathophysiology of OA

7. Patient Case Presentation

8. Further Assessment and Conservative Therapy

9. Patient Case (cont)

10. Important Considerations for Oral NSAID Use and Selection

11. Place of Opioids in Knee OA

12. Patient Case, 2 Years Later

13. IA-CS Injections for Knee OA

14. Efficacy of IA-CS Injections in Knee OA

15. Effects of IA Injection of TA on Knee Pain and Knee Cartilage Volume

16. Concerns and Contraindications With IA-CS Use

17. IA Extended-Release Formulation of TA for Knee OA

18. Phase 3 Study on Extended-Release TA for Knee OA Pain

19. Use of Extended-Release TA in Practice

20. Overview of Other Injectable Therapies Orthobiologics

21. Patient Case (cont) When Is Knee Replacement Appropriate?

22. IA Injections in Practice

23. Investigational Therapies for OA

24. Concluding Remarks

25. Abbreviations

26. Abbreviations (cont)